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A 1977 study of kids born to females starved by the Nazis during World War II suggested that the kids had increased risk of heart disease, diabetes, stroke and hypertension. While these are a few of the same disorders which have been associated with AMPK activity in adults, those earlier links were made through AMPK’s role as a manager of cellular energy usage. Milbrandt wonders if adjustments in AMPK activity triggered by malnutrition could also be impacting stem cell activity with techniques that boost long-term health risks in developing infants. AMPK’s function reversal in stem cells calls for careful usage of the enzyme in cancers therapy, the researchers be aware. Recent studies show that stem cells may become cancerous, and in those cancers the researchers now believe it could be better to inhibit AMPK than to activate it.