Angela Huttner.

Staines, D.Phil., Thomas Strecker, Ph.D., Hans C. Stubbe, M.D., Benjamin Tsofa, Ph.D., Sherif Zaki, M.D., Ph.D., Patricia Fast, M.D., Ph.D., Vasee Moorthy, Ph.D., Laurent Kaiser, M.D., Sanjeev Krishna, Sc.D., Stephan Becker, Ph.D., Marie-Paule Kieny, Ph.D., Philip Bejon, Ph.D., Peter G. Kremsner, M.D., Marylyn M. Addo, M.D., Ph.D., and Claire-Anne Siegrist, M.D. The VSV Ebola Consortium was made beneath the auspices of the WHO to initiate phase 1 research to facilitate fast progression to stage 2 and 3 trials in affected countries.1 Live replicating viral vaccines elicit humoral and cellular immune responses against viral pathogens.2,3 A single injection of 10 million plaque-forming units of rVSV-ZEBOV protected non-human primates subjected to lethal dosages of Zaire ebolavirus.4-7 Vesicular stomatitis virus belongs to the Rhabdoviridae family.8 In livestock, wild-type VSV causes ulcerations and vesicles of the oral tissues, feet, and teats.9 Human infections are rare and asymptomatic or cause mild influenza-like illness typically, although more severe infections have been described.9-14 The wild-type virus isn’t endemic in European countries and Africa.15,16 The preclinical safety record of the rVSV vector is encouraging: among roughly 80 immunized non-human primates, none had detectable toxic results.3 Viremia associated with rVSV-ZEBOV was detected on day 2 only, suggesting fast viral clearance through the innate immune response.This supplement is and openly accessible at www These suggestions are a great source not only to AUA members, but also to physicians and patients worldwide, says J. Stuart Wolf, Jr., MD, Chair, AUA Practice Recommendations Committee. Some variation in treatment is suitable for any number of factors, but a lot of the variation in individual care is unwanted and reduces the standard of health care. The guidelines, if read and put on practice carefully, will improve the standard of patient care. Related StoriesUSPSTF recommendation against regular PSA screening may delay medical diagnosis of prostate cancerNew analysis finds five different types of prostate cancerFamily history: The most vital risk factor for prostate cancer The new guideline on the diagnosis and treatment of overactive bladder is founded on a systematic review commissioned by the Agency on Healthcare Analysis and Quality.